GABA Benzodiazepine Receptors and GABA-Ergic Neurotransmission Changes in Alcohol and Nicotine Dependency
نویسندگان
چکیده
منابع مشابه
Alcohol-sensitive GABA receptors and alcohol antagonists.
A lcohol is one of the oldest and most widely used and abused of all psychoactive drugs. Although alcohol ingestion impacts most organ systems, its effects on the brain are of considerable interest, given alcohol’s many neuropharmacological actions, including its intoxicating, sedative, anxiolytic, reinforcing, and addictive properties (1). However, elucidating the cellular and molecular target...
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By far the majority of the excitatory and inhibitory neurotransmission processes in the central nervous system are mediated by, respectively, L-glutamate and y-aminobutyrate (GABA), which at the same time serve roles as constituents of cellular intermediary metabolism (Schousboe, 198 I ) . Therefore, a discussion of the metabolism of these amino acid neurotransmitters should distinguish between...
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Flanking lateral masks enhance or weaken the detection of a low-contrast visual target. This effect depends on the target-to-mask distance. An improvement of stimulus detection can also be observed when participants imagine (i.e., retrieve from memory) the previously presented masks. In this double-blind, placebo-controlled study, we show that the gamma-aminobutyric acid-A (GABAA) receptor agon...
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Introduction The GABAA receptor of mammalian brain is a ligand-gated chloride ion channel and the site of action of a variety of pharmacologically and clinically important drugs. Thus, electrophysiological experiments in many different systems have indicated that the anxiolytic, anticonvulsant, muscle relaxant and sedative hypnotic benzodiazepines like diazepam or flunitrazepam enhance and some...
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ژورنال
عنوان ژورنال: Open Access Journal of Addiction and Psychology
سال: 2019
ISSN: 2641-6271
DOI: 10.33552/oajap.2019.01.000520